However, a simplified version of the model performed acceptably. This retrospective study attempted to externally validate a prediction model of implantation based on morphokinetics, but found that this model had a lower performance than in the original publication. When only cleavage-stage embryo transfers were considered, 356 embryos with known implantation were included in the analysis (67 embryos for day 2, 249 for day 3, and 40 for Discussion Among them, 528 transferred embryos had known implantation: 116 implanted, and 412 did not (overall IR 22%). A total of 2,240 fully annotated fertilized embryos were considered. Demographic and cycle characteristics are presented in Table 1. Our population consisted in 450 couples undergoing ICSI cycle with the EmbryoScope.

Our procedures were approved by the institutional review board. All the patients gave written informed consent for the procedures, for digital recording, and for the use of data related to their medical history. This retrospective observational study was conducted on all intracytoplasmic sperm injection (ICSI) cycles performed with the EmbryoScope (Unisense Fertilitech) between February 2011 and December 2013 in the IVF unit of the University Hospital of Nantes in Nantes, France.

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